Experimental murine scedosporiosis: histopathology and azole treatment.
The histopathology of clinical isolates of Scedoporium apiospermum, S. boydii and S. aurantiacum, was evaluated in immunosuppressed mice. The organs most affected were brain, kidneys and spleen. S. aurantiacum produced more tissue damage than the other two species. AMB was ineffective in the treatment of murine infections caused by such isolates and posaconazole and voriconazole showed efficacy that correlated with the in vitro susceptibility data.
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