[The content of protein S-100 and tumor-necrosis factor-alpha in the serum of patients with discirculatory encephalopathy.]
To study the content of protein S-100 and tumor-necrosis factor-alpha (TNF-alpha ) in the serum of patients with discirculatory encephalopathy (DE), stages I and II, 108 patients have been examined. The diagnosis of vascular damage of the brain has been confirmed by ultrasound and MRI-examination. Patients with DE, stage II, had significantly higher levels of protein S-100 and TNF-alpha (0,764+/-0,021 optical density units (ODU) and 0,797+/-0,039 pg/l, respectively) compared to the control group (0,540+/-0,015 ODU and 0,528+/-0,001 pg/l; p<0,001). Lesser differences were found between patients with stage II and stage I. The levels of protein S-100 and TNF-alpha increased with age and illness duration (p<0,05). The data obtained can be used in diagnostics of chronic cerebral blood circulation disorders and prognosis of disease outcome.
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